Sargassum horneri ethanol extracts (SHE) suppressed the infiltration of CD11c⁺ cells in skin and ear of 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mice. Representative photographs of CD11c⁺ cells (arrowheads) infiltrated in skin (I–V) and ear (VI–X) are shown (A). The number of CD11c ⁺ cells per site in skin (B) and ear (C) are analyzed. Data are presented as the mean ± standard error. *p < 0.05 and **p < 0.005 indicate significant increase compared to naïve group. ^†p < 0.05 and ^††p < 0.005 indicate significant decrease compared to DNCB group. Scale bars represent: 25 μm.